abstract：:Global efforts to address schistosomiasis and soil-transmitted helminthiases (STH) include deworming programs for school-aged children that are made possible by large-scale drug donations. Decisions on these mass drug administration (MDA) programs currently rely on microscopic examination of clinical specimens to dete...

journal_title：PLoS neglected tropical diseases

authors： Hawkins KR,Cantera JL,Storey HL,Leader BT,de Los Santos T

更新日期：2016-12-22 00:00:00

abstract：BACKGROUND:Melioidosis is a tropical infectious disease associated with significant mortality due to early onset of sepsis. OBJECTIVE:We sought to review case reports of melioidosis from Malaysia. METHODS:We conducted a computerized search of literature resources including PubMed, OVID, Scopus, MEDLINE and the COCHRA...

journal_title：PLoS neglected tropical diseases

authors： Kingsley PV,Leader M,Nagodawithana NS,Tipre M,Sathiakumar N

更新日期：2016-12-22 00:00:00

abstract：BACKGROUND:With approximately 3 billion people at risk of acquiring the infection, dengue fever is now considered the most important mosquito-borne viral disease in the world, with 390 million dengue infections occurring every year, of which 96 million manifest symptoms with any level of disease severity. Treatment of ...

journal_title：PLoS neglected tropical diseases

authors： Aguiar M,Stollenwerk N,Halstead SB

更新日期：2016-12-21 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0005006.]. ...

journal_title：PLoS neglected tropical diseases

authors： Tadesse G

更新日期：2016-12-20 00:00:00

abstract：:A cross sectional serological survey of arboviral infections in humans was conducted on the three islands of the Union of Comoros, Indian Ocean, in order to test a previously suggested contrasted exposure of the three neighboring islands to arthropod-borne epidemics. Four hundred human sera were collected on Ngazidja ...

journal_title：PLoS neglected tropical diseases

authors： Dellagi K,Salez N,Maquart M,Larrieu S,Yssouf A,Silaï R,Leparc-Goffart I,Tortosa P,de Lamballerie X

更新日期：2016-12-15 00:00:00

abstract：BACKGROUND:The global burden of diarrhea is a leading cause of morbidity and mortality worldwide. In montane areas of South-East Asia such as northern Laos, recent changes in land use have induced increased runoff, soil erosion and in-stream suspended sediment loads, and potential pathogen dissemination. To our knowled...

journal_title：PLoS neglected tropical diseases

authors： Boithias L,Choisy M,Souliyaseng N,Jourdren M,Quet F,Buisson Y,Thammahacksa C,Silvera N,Latsachack K,Sengtaheuanghoung O,Pierret A,Rochelle-Newall E,Becerra S,Ribolzi O

更新日期：2016-12-09 00:00:00

abstract：:P. vivax and P. falciparum parasites display different tropism for host cells and induce very different clinical symptoms and pathology, suggesting that the immune responses required for protection may differ between these two species. However, no study has qualitatively compared the immune responses to P. falciparum ...

journal_title：PLoS neglected tropical diseases

authors： Burel JG,Apte SH,McCarthy JS,Doolan DL

更新日期：2016-12-08 00:00:00

abstract：BACKGROUND:Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This study aimed to investigate evidence of myotoxicity in Russell's viper envenoming, response to antive...

journal_title：PLoS neglected tropical diseases

authors： Silva A,Johnston C,Kuruppu S,Kneisz D,Maduwage K,Kleifeld O,Smith AI,Siribaddana S,Buckley NA,Hodgson WC,Isbister GK

更新日期：2016-12-02 00:00:00

abstract：:The human mutilating disease chromoblastomycosis is caused by melanized members of the order Chaetothyriales. To assess population diversity among 123 clinical strains of agents of the disease in Brazil we applied sequencing of the rDNA internal transcribed spacer region, and partial cell division cycle and β-tubulin ...

journal_title：PLoS neglected tropical diseases

authors： Gomes RR,Vicente VA,Azevedo CM,Salgado CG,da Silva MB,Queiroz-Telles F,Marques SG,Santos DW,de Andrade TS,Takagi EH,Cruz KS,Fornari G,Hahn RC,Scroferneker ML,Caligine RB,Ramirez-Castrillon M,de Araújo DP,Heidrich D,Co

更新日期：2016-11-28 00:00:00

abstract：BACKGROUND:The initial response to Leishmania parasites is essential in determining disease development or resistance. In vitro, a divergent response to Leishmania, characterized by high or low IFN-γ production has been described as a potential tool to predict both vaccine response and disease susceptibility in vivo. ...

journal_title：PLoS neglected tropical diseases

authors： Carneiro MW,Fukutani KF,Andrade BB,Curvelo RP,Cristal JR,Carvalho AM,Barral A,Van Weyenbergh J,Barral-Netto M,de Oliveira CI

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is highly prevalent in the Indian state of Bihar and, without proper diagnosis and treatment, is associated with high fatality. However, lack of efficient reporting mechanism had been an impediment in estimating the burden of mortality and its antecedents among symptomatic VL case...

journal_title：PLoS neglected tropical diseases

authors： Das A,Karthick M,Dwivedi S,Banerjee I,Mahapatra T,Srikantiah S,Chaudhuri I

更新日期：2016-11-21 00:00:00

abstract：:For scientists working on gonochoric organisms, determining sex can be crucial for many biological questions and experimental studies, such as crossbreeding, but it can also be a challenging task, particularly when no sexual dimorphism is visible or cannot be directly observed. In metazoan parasites of the genus Schis...

journal_title：PLoS neglected tropical diseases

authors： Kincaid-Smith J,Boissier J,Allienne JF,Oleaga A,Djuikwo-Teukeng F,Toulza E

更新日期：2016-11-18 00:00:00

abstract：:Apicomplexa tick-borne hemoparasites, including Babesia bovis, Babesia microti, and Theileria equi are responsible for bovine and human babesiosis and equine theileriosis, respectively. These parasites of vast medical, epidemiological, and economic impact have complex life cycles in their vertebrate and tick hosts. La...

journal_title：PLoS neglected tropical diseases

authors： Alzan HF,Knowles DP,Suarez CE

更新日期：2016-11-10 00:00:00

abstract：:In resource-limited settings, the scarcity of skilled personnel and adequate laboratory facilities makes the differential diagnosis of fevers complex [1-5]. Febrile illnesses are diagnosed clinically in most rural centers, and both Rapid Diagnostic Tests (RDTs) and clinical algorithms can be valuable aids to health wo...

journal_title：PLoS neglected tropical diseases

authors： Alirol E,Horie NS,Barbé B,Lejon V,Verdonck K,Gillet P,Jacobs J,Büscher P,Kanal B,Bhattarai NR,El Safi S,Phe T,Lim K,Leng L,Lutumba P,Mukendi D,Bottieau E,Boelaert M,Rijal S,Chappuis F

更新日期：2016-11-03 00:00:00

abstract：:Helminth parasites are an assemblage of two major phyla of nematodes (also known as roundworms) and platyhelminths (also called flatworms). These parasites are a major human health burden, and infections caused by helminths are considered under neglected tropical diseases (NTDs). These infections are typified by limit...

journal_title：PLoS neglected tropical diseases

authors： Sharma A,Sharma M,Yogavel M,Sharma A

更新日期：2016-11-02 00:00:00

abstract：:The Global Programme to Eliminate Lymphatic Filariasis has made significant progress toward interrupting transmission of lymphatic filariasis (LF) through mass drug administration (MDA). Operational challenges in defining endpoints of elimination programs include the need to determine appropriate post-MDA surveillance...

journal_title：PLoS neglected tropical diseases

authors： Lau CL,Won KY,Lammie PJ,Graves PM

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Buruli ulcer (BU) is a subcutaneous skin disease listed among the neglected tropical diseases by the World Health Organization (WHO). Early case detection and management is very important to reduce morbidity and the accompanied characteristic disfiguring nature of BU. Since diagnosis based on clinical eviden...

journal_title：PLoS neglected tropical diseases

authors： Sakyi SA,Aboagye SY,Otchere ID,Liao AM,Caltagirone TG,Yeboah-Manu D

更新日期：2016-10-24 00:00:00

abstract：:Accumulating evidences have assigned a central role to parasite-derived proteins in immunomodulation. Here, we report on the proteomic identification and characterization of immunomodulatory excretory-secretory (ES) products from the metacestode larva (tetrathyridium) of the tapeworm Mesocestoides corti (syn. M. vogae...

journal_title：PLoS neglected tropical diseases

authors： Vendelova E,Camargo de Lima J,Lorenzatto KR,Monteiro KM,Mueller T,Veepaschit J,Grimm C,Brehm K,Hrčková G,Lutz MB,Ferreira HB,Nono JK

更新日期：2016-10-13 00:00:00

abstract：BACKGROUND:Mosquitoes feed on plant-derived fluids such as nectar and sap and are exposed to bioactive molecules found in this dietary source. However, the role of such molecules on mosquito vectorial capacity is unknown. Weather has been recognized as a major determinant of the spread of dengue, and plants under abiot...

journal_title：PLoS neglected tropical diseases

authors： Nunes RD,Ventura-Martins G,Moretti DM,Medeiros-Castro P,Rocha-Santos C,Daumas-Filho CR,Bittencourt-Cunha PR,Martins-Cardoso K,Cudischevitch CO,Menna-Barreto RF,Oliveira JH,Gusmão DS,Alves Lemos FJ,Alviano DS,Oliveira PL,Low

更新日期：2016-10-12 00:00:00

abstract：OBJECTIVE:We evaluated the profile of patients referred to the Fiocruz Outpatient Clinic, a reference center for the diagnosis and treatment of leprosy in Rio de Janeiro, RJ, and analyzed the origins and outcomes of these referrals. METHODS:This is an observational retrospective study based on information collected fr...

journal_title：PLoS neglected tropical diseases

authors： Barbieri RR,Sales AM,Hacker MA,Nery JA,Duppre NC,Machado AM,Moraes MO,Sarno EN

更新日期：2016-10-12 00:00:00

abstract：BACKGROUND:Cutaneous dirofilariosis is a canine mosquito-borne zoonosis that can cause larva migrans disease in humans. Dirofilaria repens is considered an emerging pathogen occurring with high prevalence in Mediterranean areas and many parts of tropical Asia. In Hong Kong, a second species, Candidatus Dirofilaria hong...

journal_title：PLoS neglected tropical diseases

authors： Yilmaz E,Fritzenwanker M,Pantchev N,Lendner M,Wongkamchai S,Otranto D,Kroidl I,Dennebaum M,Le TH,Anh Le T,Ramünke S,Schaper R,von Samson-Himmelstjerna G,Poppert S,Krücken J

更新日期：2016-10-11 00:00:00

abstract：:Genomic data generated from clinical Vibrio cholerae O1 isolates collected over a five year period in an area of Kolkata, India with seasonal cholera outbreaks allowed a detailed genetic analysis of serotype switching that occurred from Ogawa to Inaba and back to Ogawa. The change from Ogawa to Inaba resulted from mut...

journal_title：PLoS neglected tropical diseases

authors： Karlsson SL,Thomson N,Mutreja A,Connor T,Sur D,Ali M,Clemens J,Dougan G,Holmgren J,Lebens M

更新日期：2016-10-05 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei is a soil saprophytic bacterium that causes melioidosis. The infection occurs through cutaneous inoculation, inhalation or ingestion. Bacteriophages (phages) in the same ecosystem may significantly impact the biology of this bacterium in the environment, and in their culturability i...

journal_title：PLoS neglected tropical diseases

authors： Withatanung P,Chantratita N,Muangsombut V,Saiprom N,Lertmemongkolchai G,Klumpp J,Clokie MR,Galyov EE,Korbsrisate S

更新日期：2016-09-26 00:00:00

abstract：:Host and parasite gene expression in skin biopsies from Leishmania braziliensis-infected patients were simultaneously analyzed using high throughput RNA-sequencing. Biopsies were taken from 8 patients with early cutaneous leishmaniasis and 17 patients with late cutaneous leishmaniasis. Although parasite DNA was found ...

journal_title：PLoS neglected tropical diseases

authors： Christensen SM,Dillon LA,Carvalho LP,Passos S,Novais FO,Hughitt VK,Beiting DP,Carvalho EM,Scott P,El-Sayed NM,Mosser DM

更新日期：2016-09-15 00:00:00

abstract：INTRODUCTION:Neglected tropical diseases produce an enormous burden on many of the poorest and most disenfranchised populations in sub-Saharan Africa. Similar to other developing areas throughout the world, this region's dearth of skilled health providers renders Western-style primary care efforts to address such disea...

journal_title：PLoS neglected tropical diseases

authors： Corley AG,Thornton CP,Glass NE

更新日期：2016-09-15 00:00:00

abstract：:Aedes aegypti is the primary vector of several medically relevant arboviruses including dengue virus (DENV) types 1-4. Ae. aegypti transmits DENV by inoculating virus-infected saliva into host skin during probing and feeding. Ae. aegypti saliva contains over one hundred unique proteins and these proteins have diverse ...

journal_title：PLoS neglected tropical diseases

authors： Conway MJ,Londono-Renteria B,Troupin A,Watson AM,Klimstra WB,Fikrig E,Colpitts TM

更新日期：2016-09-15 00:00:00

abstract：BACKGROUND:During recent West Nile virus (WNV) outbreaks in the US, half of the reported cases were classified as neuroinvasive disease. WNV neuroinvasion is proposed to follow two major routes: hematogenous and/or axonal transport along the peripheral nerves. How virus spreads once within the central nervous system (C...

journal_title：PLoS neglected tropical diseases

authors： Maximova OA,Bernbaum JG,Pletnev AG

更新日期：2016-09-12 00:00:00

abstract：BACKGROUND:Even though human hookworm infection is highly endemic in many countries throughout the world, its global economic and health impact is not well known. Without a better understanding of hookworm's economic burden worldwide, it is difficult for decision makers such as funders, policy makers, disease control o...

journal_title：PLoS neglected tropical diseases

authors： Bartsch SM,Hotez PJ,Asti L,Zapf KM,Bottazzi ME,Diemert DJ,Lee BY

更新日期：2016-09-08 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0004618.]. ...

journal_title：PLoS neglected tropical diseases

authors： Kroidl I,Saathoff E,Maganga L,Clowes P,Maboko L,Hoerauf A,Makunde WH,Haule A,Mviombo P,Pitter B,Mgeni N,Mabuye J,Kowuor D,Mwingira U,Malecela MN,Löscher T,Hoelscher M

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is a surface protein that can generate protective immunity, we hypothesized that Mp1p and/or its homolo...

journal_title：PLoS neglected tropical diseases

authors： Woo PC,Lau SK,Lau CC,Tung ET,Chong KT,Yang F,Zhang H,Lo RK,Cai JP,Au-Yeung RK,Ng WF,Tse H,Wong SS,Xu S,Lam WH,Tse MK,Sze KH,Kao RY,Reiner NE,Hao Q,Yuen KY

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:Sporadic Japanese encephalitis (JE) cases still have been reported in Zhejiang Province in recent years, and concerns about vaccine cross-protection and population-level immunity have been raised off and on within the public health sphere. Genotype I (GI) has replaced GIII as the dominant genotype in Asian c...

journal_title：PLoS neglected tropical diseases

authors： Pan JR,Yan JY,Zhou JY,Tang XW,He HQ,Xie RH,Mao HY,Zhang YJ,Xie SY

更新日期：2016-08-25 00:00:00

abstract：:Between March 2014 and July 2015 at least 10,500 Ebola cases including more than 4,800 deaths occurred in Liberia, the majority in Monrovia. However, official numbers may have underestimated the size of the outbreak. Closure of health facilities and mistrust in existing structures may have additionally impacted on all...

journal_title：PLoS neglected tropical diseases

authors： Kuehne A,Lynch E,Marshall E,Tiffany A,Alley I,Bawo L,Massaquoi M,Lodesani C,Le Vaillant P,Porten K,Gignoux E

更新日期：2016-08-23 00:00:00

abstract：BACKGROUND:Leptospirosis is a neglected zoonosis affecting animals and humans caused by infection with Leptospira. The bacteria can survive outside of hosts for long periods of time in soil and water. While identification of Leptospira species from human cases and animal reservoirs are increasingly reported, little is ...

journal_title：PLoS neglected tropical diseases

authors： Mason MR,Encina C,Sreevatsan S,Muñoz-Zanzi C

更新日期：2016-08-16 00:00:00

abstract：:The immunomodulatory properties of lipophosphoglycans (LPG) from New World species of Leishmania have been assessed in Leishmania infantum and Leishmania braziliensis, the causative agents of visceral and cutaneous leishmaniasis, respectively. This glycoconjugate is highly polymorphic among species with variation in s...

journal_title：PLoS neglected tropical diseases

authors： Nogueira PM,Assis RR,Torrecilhas AC,Saraiva EM,Pessoa NL,Campos MA,Marialva EF,Ríos-Velasquez CM,Pessoa FA,Secundino NF,Rugani JN,Nieves E,Turco SJ,Melo MN,Soares RP

更新日期：2016-08-10 00:00:00

abstract：UNLABELLED:CELADEN was a randomized placebo-controlled trial of 50 patients with confirmed dengue fever to evaluate the efficacy and safety of celgosivir (A study registered at ClinicalTrials.gov, number NCT01619969). Celgosivir was given as a 400 mg loading dose and 200 mg bid (twice a day) over 5 days. Replication co...

journal_title：PLoS neglected tropical diseases

authors： Sung C,Wei Y,Watanabe S,Lee HS,Khoo YM,Fan L,Rathore AP,Chan KW,Choy MM,Kamaraj US,Sessions OM,Aw P,de Sessions PF,Lee B,Connolly JE,Hibberd ML,Vijaykrishna D,Wijaya L,Ooi EE,Low JG,Vasudevan SG

更新日期：2016-08-10 00:00:00

abstract：BACKGROUND:Amebic colitis, caused by intestinal infection with the parasite, Entamoeba histolytica, is a common cause of diarrhea worldwide. Fulminant amebic colitis is the most devastating complication of this infection, associated with both high mortality and morbidity. We conducted a review of the English literature...

journal_title：PLoS neglected tropical diseases

authors： Shirley DA,Moonah S

更新日期：2016-07-28 00:00:00

abstract：BACKGROUND:Sensitization to Anisakis spp. can produce allergic reactions after eating raw or undercooked parasitized fish. Specific IgE is detected long after the onset of symptoms, but the changes in specific IgE levels over a long follow-up period are unknown; furthermore, the influence of Anisakis spp. allergen expo...

journal_title：PLoS neglected tropical diseases

authors： Carballeda-Sangiao N,Rodríguez-Mahillo AI,Careche M,Navas A,Moneo I,González-Muñoz M

更新日期：2016-07-22 00:00:00

abstract：:ELISA-based methods of detecting Fasciola cathepsins in feces are powerful techniques for diagnosing infections by F. hepatica and F. gigantica. In the last decade, the in-house MM3-COPRO ELISA and its commercial version BIO K 201 (BIO X Diagnostics, Belgium) have been recognized as useful tools for detecting early in...

journal_title：PLoS neglected tropical diseases

authors： Martínez-Sernández V,Orbegozo-Medina RA,González-Warleta M,Mezo M,Ubeira FM

更新日期：2016-07-20 00:00:00

abstract：:An estimated 60,000 people die of rabies annually. The vast majority of cases of human rabies develop following a bite from an infected dog. Rabies can be controlled in both human and canine populations through widespread vaccination of dogs. Rabies is particularly problematic in Malawi, costing the country an estimat...

journal_title：PLoS neglected tropical diseases

authors： Gibson AD,Handel IG,Shervell K,Roux T,Mayer D,Muyila S,Maruwo GB,Nkhulungo EM,Foster RA,Chikungwa P,Chimera B,Bronsvoort BM,Mellanby RJ,Gamble L

更新日期：2016-07-14 00:00:00

abstract：BACKGROUND:Cutaneous leishmaniasis (CL) is a major public health concern in Turkey and Sanliurfa represents the most endemic city in Turkey. Although children are most commonly affected by CL, detailed studies of pediatric CL in Turkey are lacking. METHODOLOGY/PRINCIPAL FINDINGS:In this report we retrospectively evalu...

journal_title：PLoS neglected tropical diseases

authors： Aksoy M,Doni N,Ozkul HU,Yesilova Y,Ardic N,Yesilova A,Ahn-Jarvis J,Oghumu S,Terrazas C,Satoskar AR

更新日期：2016-07-14 00:00:00